$re = '/((?:w|W)ells (?:M|m)ail(?:B|b)ox (?:Managment|Management|managment|management) (?:C|c)enter)/im';
$str = '
Wells managment has shared a mandetory file with you
Wells MailBox Managment Center
wells mailbox management center
';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php