const regex = /((?:w|W)ells (?:M|m)ail(?:B|b)ox (?:Managment|Management|managment|management) (?:C|c)enter)/igm;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('((?:w|W)ells (?:M|m)ail(?:B|b)ox (?:Managment|Management|managment|management) (?:C|c)enter)', 'igm')
const str = `
Wells managment has shared a mandetory file with you
Wells MailBox Managment Center
wells mailbox management center
`;
const subst = ``;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions