$re = '/\D*?(\d{3})\D*?(\d{3})\D*?(\d{4})\s?(.*)/m';
$str = '604 685 3361 ext. 106
250 - 590 - 6573
2505906573
2505906573
1 250 729 8225';
preg_match($re, $str, $matches, PREG_OFFSET_CAPTURE, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php