use strict;
my $str = '<span style="color: red;font-family:\'Sanc\';">test</span>
<span style="font-family:\'Sanc\';color: red;">test</span>
<span style="font-family:\'Sanc\'">test</span>
<span style="color: red;font-family:\'Sanc\';line-height: 15px;">test</span>';
my $regex = qr/(font-family):\s*([^;]*)[;'][;"]/p;
my $subst = '"';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html