$re = '/\b0+\B/m';
$str = '092.01.001.220
192.16.092.000
02.1.001.01
010.064.214.210
010.064.000.150
010.000064.017.001
127.00000.0.001
10.0.00.000
010.064.105.201';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php