$re = '/^\s*[0-9]* *([a-zA-Z]+[0-9]*)+( *\+ *[0-9]*([a-zA-Z]{1,2}[0-9]*))*\s*$/m';
$str = 'A + B
2H2 + O2
2H2O
C + O2
2H2O
2H2O
2H2O ';
$subst = "";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php