$re = '/^\s*(?:[a-z]{2,}\.\s*)?(?:[a-zñ]{2,}\s*[a-zñ ]*,\s*[a-zñ]+\s*[a-zñ ]*(?:[a-zñ]\.?\s*){0,3}|[a-zñ]+\s*[a-zñ ]*\s+(?:[a-zñ]\.?\s*){0,3}[a-zñ]{2,}\s*[a-zñ ]*)\s*(?:[a-zñ., ])*$/im';
$str = '1
Christopher Quimpo
Christopher P. Quimpo
Engr. Christopher P. Quimpo
Z G. Gono
Qu, C
Engr. Q, C
Christopher Quimpo
1
Christopher
1
Q C
1';
$subst = "col.Add \"$1\"";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php