re = /^(?=.*[а-я])(?=.*[А-Я])[а-яА-Я]+$/m
str = 'qwerty1
QWERTY1q
qwERTy
QWERTY1
QWER TY1q
Мама
авТо
гриБ
Яблоко
яБлоко
ябЛоко
яблОко
яблоКо
яблокО
агент007
стриж
ГТО
Три богатыря'
subst = ''
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html