$re = '/(?<=\D)(?=\d)|(?<=\d)(?=\D)/m';
$str = 'a3:2bc/12.3\\efg;123.12a:5,|i(+/-)j.
BENZENEACETIC ACID, .ALPHA.-HYDROXY-, (+/-)-, COMPD. WITH 1,3,5,7-TETRAAZATRICYCLO((3.3.1.1(SUP 3,7))DECANE (1:1)
Text
ibuprofen
ibuprofen;
ibuprofen.
ibuprofen:
ibuprofen(Ibumetin)
ibuprofen,enalapril
ibuprofen|enalapril
:ibuprofen
-ibumetin,
ibuprofen/enalapril
ibuprofen / enalapril
';
$subst = " ";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php