use strict;
my $str = '2124567890
212-456-7890
(212)456-7890
(212)-456-7890
212.456.7890
212 456 7890
+12124567890
+12124567890
+1 212.456.7890
+212-456-7890
1-212-456-7890
1-21-345-7890
';
my $regex = qr/(\d{1})[-](\d{3})[-](\d{3})[-](\d{4})/mp;
my $subst = '';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html