$re = '/(?<=\d{6})(\d+)(?=\d{4})/U';
$str = '4548812049400004
5229782641993099
345678000000007
6362970000457013';
$subst = "X";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php