const regex = /([\W\S]\s[\w\W]{2}.+),\s(.+)\1([!?.])/gmi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('([\\W\\S]\\s[\\w\\W]{2}.+),\\s(.+)\\1([!?.])', 'gmi')
const str = `Dios mÃo, ¡está aquÃ, está aquÃ, está aquÃ!
¿Qué paso, qué paso?
Me rehúso, me rehúso.
No, no, no, no.`;
const subst = `$1$3`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions