$re = '/(?<!\/)(\/(?=\b).+)\[(\d+), (\d+)\]/m';
$str = '// test /Users/zachhardesty/MEGA/ibm/webui/WEB_UI_CONTENT_REACT/src/modules/IdentitySources/Components/index.ts[1, 1]';
$subst = "$1:$2";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php