re = /(?:\s|\G)\d+?\K(?=(?:\d{3})+(?!\S))/
str = '403
123456
55324673 cups of tea and 1564 polar bears
ABC123131'
subst = ','
result = str.gsub(re, subst)
# Print the result of the substitution
puts result
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Ruby, please visit: http://ruby-doc.org/core-2.2.0/Regexp.html