$re = '/([^A-Za-z]|\b)+DR([^A-Za-z]|\b)+/';
$str = 'DR. This is my test string I want to match dr occurences of the case-sensitive word DR. I want all matches where DR is by itself and not part of a word such as DRIFT. I want to find it in the start of and end of a string. DR';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php