#include <MsgBoxConstants.au3> ; to declare the Constants of MsgBox
Local $sRegex = "(?m)^((?!\.)[\w\d](?!.*\.\.)[a-zA-Z0-9\.!#$%&'*+\-\/=?^_`{|}~]*[^\.\s])@([a-zA-Z][a-zA-Z\d-]+[a-zA-Z\d]+\.)+[a-zA-Z]{2,6}$"
Local $sString = "contact@regex101.com"
Local $sSubst = "-"
Local $sResult = StringRegExpReplace($sString, $sRegex, $sSubst)
MsgBox($MB_SYSTEMMODAL, "Result", $sResult)
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for AutoIt, please visit: https://www.autoitscript.com/autoit3/docs/functions/StringRegExp.htm