$re = '/,(?![^(]*\))/mi';
$str = 'ISNULL(column, 0),column2 alias, column3,ISNULL(column, 0, alksd, dlsaksla),column2 alias, array_position(ARRAY[\'f\', \'p\', \'i\', \'a\']::varchar[], x_field),column3,ISNULL(column, 0),column2 alias, column3,ISNULL(column, 0),column2 alias, column3';
$subst = " DESC,";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php