$re = '/,([^,]*)$/m';
$str = 'http://stackoverflow.com/questions/3829483/how-to-replace-last-occurrence-of-characters-in-a-string-using-javascript
DailyStats,jlaer;priatil;uido,DailyStatsAdm
AuditEvents,aorl;atil;le;mran;uido,AuditEventsAdm
';
$subst = ";$1";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php