$re = '/Your Updated Reservation Confirmation (?:#\s?)?\d+ at .+/';
$str = 'Your Updated Reservation Confirmation # 68876759 at Holiday Inn Express.
Your Updated Reservation Confirmation at Holiday Inn Hotel & Suites - Confirmation # 64754230
Your Updated Reservation Confirmation at Crowne Plaza - Confirmation # 68003047';
preg_match($re, $str, $matches, PREG_OFFSET_CAPTURE, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php