const regex = /http(?:s)?\:\/\/boards\.(4chan|4channel)\.org\/([a-z]*)\/thread\/([0-9]*)(?:\#[0-9a-z]*)?/g;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('http(?:s)?\\:\\\/\\\/boards\\.(4chan|4channel)\\.org\\\/([a-z]*)\\\/thread\\\/([0-9]*)(?:\\#[0-9a-z]*)?', 'g')
const str = `https://boards.4chan.org/mlp/thread/5
http://boards.4chan.org/b/thread/570277846
https://boards.4chan.org/mlp/thread/19865655#q19865655
https://boards.4chan.org/mlp/thread/19775771
https://boards.4chan.org/co/thread/65737750#q65737750
https://boards.4channel.org/a/thread/241489992`;
const subst = `Thread $3 on $2 `;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions