use strict;
my $str = '-0.002506000
1
01
10
1.25
01.250
0
0002345000
0.25
0.50
0.5
0.75000
1000
0001.111
0001.5
.25
01234
-00.1
.2500
.0256
-.010';
my $regex = qr/^(\-{0,1})(?:(?:0*)(\d+))?((?:\.)(?:\d*?))?0*$/mp;
my $subst = '$1$2$3';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html