$re = '/\.gif\?([^=]+=[^=]+&)+[^=]+(=[^=]+)?"/m';
$str = '
<img src="https://media.giphy.com/media/m7jzopL8Dm1kA/giphy.gif?cid=ecf05e4785d70ac4724a4083945ea6171d95688bf6a8a282&rid=giphy.gif&ct=g" /> ';
$subst = ".gif\"";
$result = preg_replace($re, $subst, $str);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php