$re = '/^ *#define +([a-zA-Z][\w]*)\( *([a-zA-Z_]\w*)(?: *, *([a-zA-Z_]\w*) *) *\) *(.+) *$/m';
$str = ' #define AD9D9( _Xy_ , Y9_y3 ) x + y + 3';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php