$re = '/^(chr)?(1|2|3|4|5|6|7|8|9|10|11|12|13|14|15|16|17|18|19|20|21|22|X|Y)((:|\s+)\d+((-|\s+)\d+((_|\s+)[ACGT]+((\/|\s+)[ACGT]+)?)?)?)?$/i';
$str = '11 12345 54321 a t';
preg_match($re, $str, $matches, PREG_OFFSET_CAPTURE, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php