$re = '/^.+? ?, ?(A[LKSZRAP]|C[AOT]|D[EC]|F[LM]|G[AU]|HI|I[ADL N]|K[SY]|LA|M[ADEHINOPST]|N[CDEHJMVY]|O[HKR]|P[ARW]|RI|S[CD] |T[NX]|UT|V[AIT]|W[AIVY])$/i';
$str = 'los angeles, ca';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php