use strict;
my $str = '**้
็นใ **';
my $regex = qr/\*\*([\x{3041}-\x{3096}\x{30A0}-\x{30FF}\x{3400}-\x{4DB5}\x{4E00}-\x{9FCB}\x{F900}-\x{FA6A}\x{2E80}-\x{2FD5}\x{FF5F}-\x{FF9F}\x{3000}-\x{303F}\x{31F0}-\x{31FF}\x{3220}-\x{3243}\x{3280}-\x{337F}]+)\*\*/mp;
my $subst = '<b>$1</b>';
my $result = $str =~ s/$regex/$subst/rg;
print "The result of the substitution is' $result\n";
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for Perl, please visit: http://perldoc.perl.org/perlre.html