$re = '/^(?:https:\/\/)*(?:localhost|airhelp.com)\/(?!en|nl|pt).*\/.*$/m';
$str = '/en/airlines/
localhost/en-gb/airlines/
localhost/en-gb/
localhost/pl/
localhost/nl/
localhost/pt/
localhost/pt-br/
airhelp.com/pl/
airhelp.com/en/
airhelp.com/en-gb/
airhelp.com/pt/
airhelp.com/pl/airlines/dupa
https://localhost/en/
https://localhost/en-gb/
https://localhost/pl/
https://localhost/nl/
https://localhost/pt/
https://localhost/pt-br/
https://airhelp.com/pl/
https://airhelp.com/en/
https://airhelp.com/en-gb/
https://airhelp.com/pt/';
preg_match_all($re, $str, $matches, PREG_SET_ORDER, 0);
// Print the entire match result
var_dump($matches);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php