const regex = /<iframe.*?(width="[0-9]*")?\.?(height="[0-9]*")?\.*?src=".*?youtube\.com\/embed\/(\w*\-?\w*).*?(width="[0-9]*")?\.?(height="[0-9]*")?\.*?><\/iframe>/gim;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('<iframe.*?(width="[0-9]*")?\\.?(height="[0-9]*")?\\.*?src=".*?youtube\\.com\\\/embed\\\/(\\w*\\-?\\w*).*?(width="[0-9]*")?\\.?(height="[0-9]*")?\\.*?><\\\/iframe>', 'gim')
const str = `<iframe width="123" height="237"src="http://www.youtube.com/embed/IMtG_n1FpgA" frameborder="0" allowfullscreen></iframe>
<iframe width="560" height="315" src="https://www.youtube.com/embed/VsG2t-rKUmA" frameborder="0" allowfullscreen></iframe>
<iframe id="cKOFUZFPYp8_Youtube_api" style="width:100%;height:100%;top:0;left:0;position:absolute" frameborder="0" allowfullscreen="1" title="YouTube video player" width="640" height="360" src="https://www.youtube.com/embed/cKOFUZFPYp8?controls=0&modestbranding=1&rel=0&showinfo=0&loop=0&fs=0&hl=en&enablejsapi=1&origin=http%3A%2F%2Fspiritualtv.org&widgetid=1"></iframe>`;
const subst = `<video id=\"$3\" class=\"video-js vjs-default-skin vjs-fluid\" controls width=\"640\" height=\"264\" data-setup='{ \"techOrder\": [\"youtube\"], \"sources\": [{ \"type\": \"video/youtube\", \"src\": \"https://www.youtube.com/watch?v=$3\"}] }'></video>`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions