const regex = /([a-z]+|\d+[a-z]*|\([a-z0-9\s()+/*-]+?\))\s*(?:\*?\s*([a-z]+)|\*\s*(\d+[a-z]*)|\*?\s*(\([a-z0-9\s()+/*-]+?\)))\s*(\+|-)\s*(?:\1\s*(?:\*?\s*([a-z]+)|\*\s*(\d+[a-z]*)|\*?\s*(\([a-z0-9\s()+/*-]+?\)))|(?:([a-z]+)|(\d+[a-z]*)|(\([a-z0-9\s()+/*-]+?\)))\s*\*\s*\1)|(?:([a-z]+)|\*\s*(\d+[a-z]*)|\*?\s*(\([a-z0-9\s()+/*-]+?\)))\s*\*\s*([a-z]+|\d+[a-z]*|\([a-z0-9\s()+/*-]+?\))\s*(\+|-)\s*(?:\15\s*(?:\*?\s*([a-z]+)|\*\s*(\d+[a-z]*)|\*?\s*(\([a-z0-9\s()+/*-]+?\)))|(?:([a-z]+)|(\d+[a-z]*)|(\([a-z0-9\s()+/*-]+?\)))\s*\*\s*\15)/gi;
// Alternative syntax using RegExp constructor
// const regex = new RegExp('([a-z]+|\\d+[a-z]*|\\([a-z0-9\\s()+\/*-]+?\\))\\s*(?:\\*?\\s*([a-z]+)|\\*\\s*(\\d+[a-z]*)|\\*?\\s*(\\([a-z0-9\\s()+\/*-]+?\\)))\\s*(\\+|-)\\s*(?:\\1\\s*(?:\\*?\\s*([a-z]+)|\\*\\s*(\\d+[a-z]*)|\\*?\\s*(\\([a-z0-9\\s()+\/*-]+?\\)))|(?:([a-z]+)|(\\d+[a-z]*)|(\\([a-z0-9\\s()+\/*-]+?\\)))\\s*\\*\\s*\\1)|(?:([a-z]+)|\\*\\s*(\\d+[a-z]*)|\\*?\\s*(\\([a-z0-9\\s()+\/*-]+?\\)))\\s*\\*\\s*([a-z]+|\\d+[a-z]*|\\([a-z0-9\\s()+\/*-]+?\\))\\s*(\\+|-)\\s*(?:\\15\\s*(?:\\*?\\s*([a-z]+)|\\*\\s*(\\d+[a-z]*)|\\*?\\s*(\\([a-z0-9\\s()+\/*-]+?\\)))|(?:([a-z]+)|(\\d+[a-z]*)|(\\([a-z0-9\\s()+\/*-]+?\\)))\\s*\\*\\s*\\15)', 'gi')
const str = `Can be used to simplify a bit calculs as "2y - z * 2" or (4-z) (x/3 * 4) - (4-z)(1 / xy).`;
const subst = `$1$15($2$3$4$12$13$14 $5 $6$7$8$9$10$11$16$17$18$19$20$21$22)`;
// The substituted value will be contained in the result variable
const result = str.replace(regex, subst);
console.log('Substitution result: ', result);
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for JavaScript, please visit: https://developer.mozilla.org/en/docs/Web/JavaScript/Guide/Regular_Expressions