$re = '/interface GigabitEthernet1\/(1[2-9]|[1-2][0-1]).*\n(.*\n)*.* description \*\* Unused Port \*\*.*\n(.*\n)*.* switchport access vlan 1002.*\n(.*\n)*.* switchport mode access.*\n(.*\n)*.* switchport port-security.*\n(.*\n)*.* switchport port-security mac-address sticky.*\n(.*\n)*.* shutdown.*\n(.*\n)*.* no cdp enable.*\n(.*\n)*.* spanning-tree portfast
/';
$str = 'interface GigabitEthernet1/12
description ** Unused Port **
switchport access vlan 1002
switchport mode access
switchport port-security
switchport port-security mac-address sticky
shutdown
no cdp enable
spanning-tree portfast
!
interface GigabitEthernet1/13
description ** Unused Port **
switchport access vlan 1002
switchport mode access
switchport port-security
switchport port-security mac-address sticky
shutdown
no cdp enable
spanning-tree portfast
!
';
$subst = "";
$result = preg_replace($re, $subst, $str, 1);
echo "The result of the substitution is ".$result;
Please keep in mind that these code samples are automatically generated and are not guaranteed to work. If you find any syntax errors, feel free to submit a bug report. For a full regex reference for PHP, please visit: http://php.net/manual/en/ref.pcre.php